![]() Once you're done, pass it along to all your friends who've never watched Leslie and the gang because they love "The Office" so much. Whether you've just binged the entire series or have been meaning to rewatch your favorite episodes for a while, take our quiz to see if you can match the "Parks and Rec" quotes to the character. A list of all characters in Parks and Recreation. Buttons"? We know you're itching to show off your "Parks and Rec" knowledge! including director of recreation, head of player development and head coach for. You may know which character said "Ovaries before brovaries," but who calls wine "crying juice"? Is it Leslie or Ben who named their calculator "Dr. All characters of Parks and Rec seem to be humble and friendly characters that you would want as your own friend. a trendsetter in skill development and youth leadership as well as. Sure, he’s not technically a person, but that doesn’t make him any less of a stabilizing, peaceful presence. Everyone loves him because, as a miniature horse, Lil Sebastian has a heart of gold. Can you match all theses "Parks and Rec" quotes to the character?Įven true fans will find this quiz to be as difficult as telling whether or not April is actually being serious. But we can’t talk about Parks and Rec without bringing up Lil Sebastian, who is even-tempered, consistent, and loyal to the people of Pawnee. You too? We thought so! To commemorate one of the best shows EVER, we've put together a quiz to test your fan status. of Mac ProgrammingDan Parks Sydow, Wreckless Love (Trendsetters Publications. His Ne is all over the place and his reasoning and conclusions are very irrational, Fi. And for the record, after watching some PaR, Andy is a definite ENFP character. Tom could have easily been an annoying character, but the show did a great job of finding a balance. Storytelling to Teach Character and Prevent BullyingElisa Davy Pearmain. I was asking because someone said somewhere that they could tell from an interview that someone had too much Se to be something. His high energy and need to pamper himself are great fun to watch. Sure, there are a lot of great shows on television, but if we're being honest, nothing has ever made us laugh quite as hard as "Parks and Recreation." Between Ron Swanson eating ALL the breakfast food to Donna and Tom's "treat yo' self," it's as if the show had a direct line to our funny bone. Tom Haverford In the small town of Pawnee, Tom Haverford is someone who sees himself as a big city hustler. ![]()
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11/25/2023 0 Comments Star trek the motion picture![]() ![]() TMP is divorced from the rest of Kirk's time in Trek through being set in this gap and provides just a small peek at this unknown period. The period of time from the end of the 5 year mission to the beginning of TWOK is an immense source of speculation and interest for fans and scores of unofficial books have been set in this period. ![]() All the remaining films are set after each other leading up to the final mission of the original crew and Kirk's death. Consider, we have the original 5 year mission which was followed by this movie (not counting the animated series)there is then a 14 year gap, fictionally as it were in time from the end of TMP and The Wrath of Khan (TWOK). It is interesting that this is the only visualisation of a lost period in Star Trek's fictional timeline. Star Trek The Motion Picture (TMP)is my favourite film in the entire series. To learn more about how and for what purposes Amazon uses personal information (such as Amazon Store order history), please visit our Privacy Notice. You can change your choices at any time by visiting Cookie Preferences, as described in the Cookie Notice. ![]() Click ‘Continue without accepting’ or ‘Customise Cookies’ to decline these cookies, make more detailed choices or learn more. Third parties use cookies for the purposes of displaying and measuring personalised advertisements, generating audience insights, and developing and improving products. This includes using first- and third-party cookies which store or access standard device information such as a unique identifier. If you agree, we will also use cookies to complement your shopping experience across Amazon stores as described in our Cookie Notice. We also use these cookies to understand how customers use our services (for example, by measuring site visits) so we can make improvements. We use cookies and similar tools that are necessary to enable you to make purchases, to enhance your shopping experiences, and to provide our services, as detailed in our Cookie Notice. ![]() 11/25/2023 0 Comments Tp link router login archer c9![]() ![]() ![]() With the TP-LINK Archer C9 router, you can also restore the factory settings that came with the installed software.
11/24/2023 0 Comments Dendrite agate ring![]() ![]() Many agate varietal classifications are based on optical properties, while others are based on inclusions, mining localities or geographic origins. Dendritic Agate Treatmentĭendritic agate is not known to be treated or enhanced in any way.ĭendritic Agate: Other Similar or Related Gemstones: Back to Topĭendritic agate is one of the many varieties of agate stone available today. Dendritic agate can be difficult to cut because dendrites form at various depths, which means that bringing desirable patterns to the surface requires skillful cutting away of surface layers, often resulting in uneven and undulating surfaces. Free-form slabs are most common, but other common shapes include ovals, pears, rounds and other traditional shapes. Dendritic Agate Cut and Shapeĭendritic agate is typically plain-cut, most often en cabochon. Dendritic inclusions that resemble landscapes are rare and highly sought-after, especially by gemstone collectors. Dendritic agate exhibits a waxy to dull luster. Translucent specimens are most desirable. Dendritic Agate Clarity and Lusterĭendritic agate is typically translucent to opaque. Traces of iron ions will often result in slightly reddish to brown inclusions. In some cases, dendritic inclusions may form in spotted clusters rather than branching structures these are sometimes referred to as 'mosquito stones'.īuying Dendritic Agate and Determining Dendritic Agate Gemstone Value Back to Top Dendritic Agate Colorĭendritic agate is typically colorless to whitish-gray in color and accompanied by brown to black branching tree-like inclusions, owed to crystallized manganese and iron impurities. The impurities crystallize inside the agate in branching formations seeping through fine surface fractures. The iron and manganese ions gain access to the forming stone as weathering solutions from neighboring rock. 'Dendrites', a Greek word for 'tree-like', are inclusions that appear organic due to their plant-like structure, but they are actually inorganic traces of iron or manganese. It is considered to be one of the rarer and more sought-after varieties of agate stone, although it is technically not a 'true agate' since it lacks the typical banding of other agate stones. Your new jewelry comes to you beautifully packaged in white quality recyclable cardboard jewelry boxes with luxurious black gross grain ribbon and logo printed tissue paper, it’s completely ready for gift giving.About Dendritic Agate - History and Introductionĭendritic agate is a translucent, colorless to whitish-gray variety of chalcedony quartz, easily distinguished by its distinct tree- or fern-like markings known as 'dendrites', which are most often brown to black in color. I strive to create my jewelry pieces with quality materials that will be forever treasured Created by mother nature each to me is so special and a little treasure. It is also known to be helpful with creativity and the creative process.Īll my gemstones I have chosen for their unique or interesting characteristics, some have natural quirks or intricate inclusions which I love, this doesn’t make them any less beautiful it’s what makes them so unique. Please check all measurements and dimensions before purchasingĭendritic Opal Agate Brings fullness and abundance to all areas of life, known as the stone of plentitude it helps to create a peaceful environment and aids with moving forward with personal goals. This is a handcrafted fully completed piece of jewelry with no scope for alteration. Natural picture Dendritic opal gemstone 15 x 15mm round ![]() Sterling silver and fine silver bezel set No two dendrites will ever be the same and each will evoke a different scene to you which makes them so special. ![]() It’s so beautiful and magical giving the feeling of hushed falling snow on delicate foliage with birds singing among the hedges as wildlife hibernate from the harsh winter worst. Naturally created this special coin shaped Dendritic Opal scene brings to mind snowy frosted tips of hedgerow verges creating scenes of calm winter walks amid natures harshest time of year. ![]() 11/24/2023 0 Comments Open road travel trailer![]() ![]() Ensuring your tow vehicle is properly equippedīefore renting a travel trailer, you need to ensure your tow vehicle has the necessary equipment to safely tow. Tongue weight should be between 10-15 percent of the total loaded trailer weight for travel trailers.Įxceeding even one of those ratings while towing a rental trailer could not only cause damage to your vehicle, but also endanger yourself, your passengers and others. Hitch weight rating – This is the maximum weight your hitch is designed to safely carry.Gross axle weight ratings (GAWR) on both the vehicle and trailer, which represent the maximum amount of weight a particular axle can carry.Gross combined weight rating (GCWR) – This represents the maximum weight of your loaded tow vehicle and your loaded trailer combined.Gross vehicle weight rating (GVWR) – This represents the maximum weight your vehicle can carry, including passengers, cargo, fuel and the vehicle itself. ![]() While it is important not to exceed your vehicle’s Maximum Towing Capacity, there are other important weight limits that should never be exceeded while towing, including: Thus if your max towing capacity is 10,000#, you should rent a travel trailer that weighs no more than 8000#. As a general rule, you should limit your trailer weight to 80% of the Maximum Towing Capacity in order to have an adequate safety margin. This number represents the maximum trailer weight that your vehicle will safely tow in ideal conditions. Selecting a travel trailer to rent – Tow Vehicle CapacitiesĪll vehicles that are equipped to tow a trailer are given a Maximum Towing Capacity rating by the manufacturer. If you stop by our lot, we will be happy to test these for you at no charge. This will help avoid unpleasant surprises when you come to pick up your travel trailer rental. NOTE: If you are renting a travel trailer, we strongly recommend that you have your brake controller and 7-pin connector tested at least a week or two prior to your rental date. Failure to do so could endanger the safety of everyone in your vehicle. ![]() If you plan to rent a travel trailer from Open Road RVs, it is important that you understand and follow the guidelines below. If this Highland Ridge Open Range towable trailer piqued your interest, take a virtual tour on iTiny Houses.Renting a travel trailer is a terrific and cost-effective way to enjoy an RV vacation, but careful consideration must be given to your tow vehicle to ensure it is properly equipped to safely tow the rental trailer. The equally impressive bathroom hides behind a sliding door and is equipped with all the standard fittings, plus a washing machine and a medicine cabinet.įinally, the bedroom houses a comfortable king-size bed, a closet, and more cabinetry for your storage needs. It has retractable tables, a separate kitchen island, plenty of cabinets, and Corian countertops, as well as all the essentials: residential fridge, gas stove and oven, microwave, and double sink. The spacious kitchen comes fully furnished and includes everything you need to make cooking a breeze. The luxurious boho living area includes everything you’d normally find in a conventional home and more, such as a three-seater sofa, an electric fireplace, a large TV, and other storage or decorative bits. They could easily accommodate bunk beds, a desk for your working needs, or storage units. These are now beautifully decorated with extra furniture and other tidbits, but you can use them for other purposes as well. There is a boho-style living room akin to a luxury home that takes up a big part of the trailer’s interior space and two other separate living spaces on the right and left side of it. It features a neat layout, plenty of windows, white and cream hues, solid oak flooring, and the whole nine yards. Once you step inside, you will be greeted by a contemporary interior that looks just like a conventional home. On the outside, this Highland Ridge Open Range trailer exudes a contemporary look with its sleek gray exterior, but the real magic happens inside. For $65,000, you can get a spacious mobile dwelling with three times the insulation compared to other trailers available on the market, which makes a true four-season-ready tiny home on wheels.Īccording to the seller, the trailer benefits from new suspensions, roof, and resealing. The Highland Ridge Open Range travel trailer you see here is up for sale out of Sarasota, Florida, and offers no less than 430 square feet (40 square meters) of space. Highland Ridge RV is a well-known and trusted brand in the world of mobile habitats due to their sturdy builds with great insulation to ensure comfortable living all year round. RVs and travel trailers are more suitable for this category of nomads looking for off-grid adventures. ![]() 11/24/2023 0 Comments Jr graphic designer near me![]() A school setting provides ample opportunities for learning how to communicate about design, including sharing and constructively accepting criticism. Some programs even incorporate workshops where highly talented guest speakers share their insights and tips about the design profession. Also, Adobe's student discounts make getting the required software much more affordable in situations where you need to purchase it yourself.īuilt-in mentorship: Going to school for graphic design allows you to learn from teachers who may have years or decades of meaningful experience in the field. Some schools even provide laptops with all the software you need pre-installed. Formal training also gives you more credibility among other designers.įree or discounted access to design software: Most graphic design schools have computer labs where students can learn and practice their technical skills at no additional cost. Even though many employers place more value on designers' portfolios than their educational credentials, a degree, diploma, or certificate in this field is often necessary to get your foot in the door. Benefits of Attending Graphic Design Schoolīetter career prospects: People who get a formal education in graphic design tend to have more and better-paying jobs open to them compared to self-taught people. Many inexperienced graphic designers are able to build up their real-world experience through internships, volunteering, or paid freelance work. ![]() ![]() Technical training in professional design software is also a must. However, many clients and employers care more about experience and the quality and creativity of work in a graphic designer's portfolio than about their particular education. Many graphic design jobs require a degree in this field, particularly those at large or midsized organizations. ![]() 11/24/2023 0 Comments Wen jing li![]() In recent years, more and more attention is paid to intraoperative mechanical ventilation strategies, which may affect PPCs in addition to the preoperative optimization of patients’ status and operation style. Considering that approximately 234 million patients worldwide require surgical treatment under general anesthesia each year, reducing the incidence of PPCs may have a great impact on global mobility and mortality. According to the type of surgery and the definition of PPCs, the incidence of PPCs has been reported to range from 5 to 33%. It is quite certain that postoperative pulmonary complications (PPCs) result in more morbidity and mortality, as well as prolong hospital stays. Secondary endpoints will be serum IL-6, TNF-α, procalcitonin (PCT) kinetics during and after surgery, incidence of PPCs, organ dysfunction, length of in-hospital stay, and hospital expense. ![]() Primary endpoints will be postoperative atelectasis measured by chest electrical impedance tomography (EIT) and intraoperative oxygen index. Standard lung-protective ventilation methods such as low tidal volumes (7 ml/kg, predicted body weight, PBW), a fraction of inspired oxygen ≥ 0.5, and recruitment maneuvers (RM) will be applied during and after operation in both groups. ![]() A PEEP of 5 cmH 2O will be used in PEEP5 group, whereas an individualized PEEP value determined by a Cstat-directed PEEP titration procedure will be applied in the iPEEP group. They will be randomly assigned to control group (PEEP5 group) and iPEEP group. A total number of 80 obese patients with body mass index ≥ 32.5 kg/m 2 scheduled for laparoscopic gastric volume reduction and at medium to high risk for PPCs will be enrolled. This study is a single-center, two-arm, prospective, randomized control trial. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. HER2 MMAE affibody antibody drug conjugates (ADCs).Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. In the future, the design of better strategies that can prolong half-life without affecting cytotoxicity may be useful for further improving the therapeutic potential of these molecules. These results may indicate that prolonging the half-life is very helpful in improving the therapeutic capacity of miniaturized ADCs. The combined effect leads to HP10KM having the most ideal tumor therapeutic ability at the same dosages in the animal model, and its off-target toxicity was also reduced by more than 4 times compared with that of HM. Compared with the conjugate Z HER2-SMCC-MMAE (HM), which has no PEG insertion, Z HER2-PEG4K-MMAE (HP4KM) and Z HER2-PEG10K-MMAE (HP10KM) with 4 or 10 kDa PEG insertions have 2.5- and 11.2-fold half-life extensions and 4.5- and 22-fold in vitro cytotoxicity reductions, respectively. The results showed that the inserted PEG chains significantly prolonged the circulation half-life but also obviously reduced the cytotoxicity of the conjugates. In this study, we propose a novel design strategy for miniaturized ADCs in which drug molecules and small ligand proteins are site-specifically coupled via a bifunctional poly(ethylene glycol) (PEG) chain. ![]() ![]() Miniaturized ADCs may be a potential solution, although their short circulation half-life may lead to new problems. However, traditional ADCs have some limitations, such as reduced permeability in solid tumors due to the high molecular weight of monoclonal antibodies, difficulty in preparation and heterogeneity of products due to the high drug/antibody ratio (4-8 small molecules per antibody). Antibody drug conjugates (ADCs) have become an important modality of clinical cancer treatment. ![]() 11/24/2023 0 Comments Famous diogenes quotes![]() ![]() When Diogenes looked at most people, he scarcely found anyone living up to their human potential. Like dogs, they judged character well–examining people’s actions, not their titles or purses. Like dogs, Cynics lived carefree-unworried about rent, food, or manners. Diogenes owned the label, explaining that he earned the nickname by wagging his tail at those who gave him things, barking at those who didn’t, and biting bad people. Cynics earned this title by living like dogs, unconcerned for human convention and striving only for bare necessities. The word “Cynic” is almost a direct transliteration of the Greek kunikos, meaning “dog-like.” To be called “Cynic” is to be compared to a dog. Everywhere they went, they tried to convince people to abandon their material possessions and live simply and freely in nature. And third, they held a staff-a glorified walking stick that helped them to move from city to city in the ancient world. Second, each carried a pēra, a pouch that contained all their material possessions. It served not only as a garment but also as something to sleep on and in, as they had no permanent homes. ![]() First, they wore a tribōn, a threadbare cloak. The Mangy Dogs of Greece and the Natural Lives They LedĬynic philosophers were easy to recognize in the ancient world. This essay summarizes the main values in ancient Cynicism, especially those present in the life of Diogenes of Sinope. And it does so through training both the body and mind to live as simply as possible. Rather, Cynics argued that philosophy studies the lives of actual people and teaches us to live well and prepares us for any fortune. Cynics foremost rebuked civilization and valued nature.įor Diogenes and the Cynics, philosophy was not about conjuring hypothetical scenarios or pondering ancient mysteries. Yet their philosophy was more than clever refutations. Cynics were masters at using spectacle and wit to argue for their positions. He only needed a chicken and a couple of words. Diogenes didn’t need ornate theory or erudite rhetoric to disprove Plato. Cynics exercised parrēsia, or direct, plain, frank, and free speech. The story of Plato, Diogenes, and the chicken is emblematic of Cynicism. He refuted Plato by plucking a chicken, taking it to his lecture, and announcing, “Here’s Plato’s human!” He provided a flesh-and-blood example of a featherless, bipedal animal that no one would consider human. Diogenes of Sinope (404-323 BCE), the first great Cynic, fit into the second group. ![]() He thought long and hard about how to define “human” and concluded that humans are featherless, bipedal animals. Plato (429-347 BCE) fits in the first group. Standard Ebooks arenât just a beautiful addition to your digital libraryâtheyâre a high quality standard to build your own ebooks on.Some ancient Greek philosophers only used words to investigate philosophical problems. Standard Ebooks takes ebooks from sources like Project Gutenberg, formats and typesets them using a carefully designed and professional-grade style manual, fully proofreads and corrects them, and then builds them to create a new edition that takes advantage of state-of-the-art ereader and browser technology. copyright restrictions, and free of cost.Įbook projects like Project Gutenberg transcribe ebooks and make them available for the widest number of reading devices. Standard Ebooks is a volunteer-driven project that produces new editions of public domain ebooks that are lovingly formatted, open source, free of U.S. Standard Ebooksįree and liberated ebooks, carefully produced for the true book lover. Standard Ebooks: Free and liberated ebooks, carefully produced for the true book lover. ![]() 11/24/2023 0 Comments Raindrop massage essential oils![]() The oils are dispensed in little drops from a height of about six inches above the back, which is where Raindrop Technique gets its name. Essential oils are known to boost stamina and energy, help you relax, help manage stress and frustration and promote overall health, vitality, and longevity. These oils, which are high in antioxidants, are also mood elevating and antiseptic, creating an unfavorable environment for harmful viruses and bacteria that can hibernate in the body. Raindrop Technique uses a sequence of Young Living essential oils that are immune enhancing, support the body’s natural defenses, as well as the circulatory, respiratory, endocrine, digestive, nervous, and other body systems. It integrates Vitaflex and massage, utilizing the power of essential oils in bringing the body into structural and electrical alignment.” (from the Essential Oils Desk Reference) Gary Young working with a Lakota medicine man named Wallace Black Elk. ![]() Raindrop Technique originated in the 1980s from the research of Dr. During the years that it has been practiced, it has resolved numerous cases of scoliosis and kyphosis and eliminated the need for back surgery for thousands of people. “RAINDROP” technique is a powerful, non-invasive tool for assisting the body in correcting defects in the curvature of the spine. Relieves back pain and tension headaches. ![]() Some of the many therapeutic qualities are: These pathogens create inflammation, which, in turn, contorts and disfigures the spinal column. Raindrop Technique is based on the theory that many types of scoliosis and spinal misalignments are caused by viruses or bacteria that lie dormant along the spine. ![]() This treatment is a natural alternative for managing chronic pain, such as fibromyalgia and arthritis. It will help align the energy centers of the body and release them if blocked. It is designed to bring balance to the body with its relaxing and mild application. It has also been used successfully on horses and other animals. Raindrop has helped bring relief to chronic pain sufferers and has been known to cause visible improvement in scoliosis. An essential oil massage technique based on Lakota Native healing, Raindrop Therapy is the application of powerful antibacterial, anti-inflammatory, antiviral oils along the spine. ![]() 11/24/2023 0 Comments City of phoenix water quality report![]() ![]() In addition, samples are routinely collected at the Water Treatment Plants and drinking water wells to insure the quality of the water before it enters the distribution system. Both the EPA and ADEQ require water quality compliance sampling under the SDWA.Įvery month, the Water Monitoring section takes hundreds of water samples from sites throughout the City's water distribution system to test for the presence of any possible bacteria and to also monitor for chlorine levels. The city of Phoenix is responsible for delivering the attached city of Glendale Water Quality Report because the water delivered to this specific area is treated and delivered by Glendale, but billed by the City of Phoenix Water Services. Water Quality works to ensure compliance with all drinking water regulations and wastewater aquifer protection and reuse permits, and maintains the required. ![]() The city regularly monitors water quality and treats the water according to priority. For Customers of the City of Phoe nix-Hedgepeth Hills Water S ystem. ![]() This puts Glendale, like the other cities in Maricopa County in the hard to very hard category. Washington St., 9th Floor, Phoenix, AZ 85003-1611. According to the published 2019 Water Quality Report, the water hardness level ranges from 116-290 parts per million (PPM). The Environmental Services Department is responsible for approving, regulating, educating, and, in some cases, managing water, wastewater, stormwater, and waste management practices to ensure public health, sanitation, and pollution prevention. The Safe Drinking Water Act (SDWA) is the primary federal law that ensures the safety of America's drinking water. Water Quality Questions, c/o City of Phoenix Water Services Department, Environmental Services Division, 200 W. ![]() |
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